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AlzRisk Cohort Detail
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Cohort: Rotterdam Study
Website: http://www.epib.nl/research/ergo.htm
Risk Factors: Alcohol,
Blood Pressure,
Diabetes Mellitus,
Head injury,
Inflammatory Biomarkers,
Non-Steroidal Anti-Inflammatory Drugs,
Nutritional Antioxidants,
Physical Activity,
Statin use

Introduction to the Cohort
From 1990 to 1993, investigators for the Rotterdam Study recruited residents in a suburb of Rotterdam, The Netherlands to participate in their longitudinal study of chronic disease in aging. They enrolled 7,983 adults, aged 55 years and older, of whom 7,046 were deemed to be free of dementia. Since enrollment, participants have undergone evaluations every 2-3 years. Additional follow-up information is available from medical record data. At enrollment, members of the dementia-free cohort were aged, on average, 69.5 years old (SD 9.1); 60% were female (Reitz 2007).

Ethnicity Breakdown
All participants were residents of a suburb of Rotterdam, The Netherlands. No other information on ethnicity or race has been reported.

Diagnosis & Evaluation Methods
For a detailed description, see Ott A et al 1998..

References
Ott A, Breteler MM, van Harskamp F, Stijnen T, Hofman A. Incidence and risk of dementia. The Rotterdam Study. Am J Epidemiol. 1998 Mar 15;147(6):574-80.

Reitz C, den Heijer T, van Duijn C, Hofman A, Breteler MM. Relation between smoking and risk of dementia and Alzheimer disease: the Rotterdam Study. Neurology. 2007 Sep 4;69(10):998-1005.