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Non-Steroidal Anti-Inflammatory Drugs
Cardiovascular Health Cognition Study/Cardiovascular Health Study Cognition Study
The interviewers ascertained exposure information via an annual medication inventory. The investigators reported results separately for ever/never statin use, lipophilic statin use, less lipohilic statin use, current/past/never use, and duration of use. This entry pertains to results on current/past/never statin use with a 1 year time lag.
The investigators compared incident AD risk in two separate sets of comparison groups: the group of participants who formerly used statins at baseline or during follow-up up to a year prior to AD assessment, but discontinued statin therapy ("Formerly used") and the reference group of participants who did not use statins or non-statin LLAs ("Never used"); and separately, the group of participants who currently uses statins at baseline or during follow-up up to a year prior to AD assessment ("Currently uses") and the reference group of participants who did not use statins or non-statin LLAs ("Never used").
Caucasian participants contributed 91% of person-time.
Cohort members older than eighty years of age contributed fifty-four percent of person-time. The article does not provide the average age for members of this cohort.
Screening and Diagnosis Detail
Mini-Mental State Examination (Folstein 1975)
Covariates & Analysis Detail
Cox proportional hazards regression