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Non-Steroidal Anti-Inflammatory Drugs
Washington Heights-Inwood Columbia Aging Project
Vitamin intake was measured using the baseline questionnaire.
High-dose supplements of folate were considered those containing ≥400μg (the Recommended Dietary Allowances [RDA], as recommended by the Food and Nutrition Board of the Institute of Medicine).
"We assessed daily dietary intake with a 61-item semi-quantitative food frequency questionnaire (Channing Laboratory, Cambridge, MA). Information on daily dietary, supplement, and total intake of folate and vitamins B6 and B12 was estimated from the semi-quantitative food frequency questionnaire data."
Participants were a random sample of Medicare recipients 65 years or older residing in northern Manhattan (Washington Heights, Hamilton Heights, or Inwood).
Screening and Diagnosis Detail
Diagnostic and Statistical Manual IV
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia definition
: Dementia via DSM-IV.
Dementia diagnosis was made by a multidisciplinary consensus panel using both baseline and follow-up information. Dementia diagnosis was based on DSM-IV criteria and required evidence of cognitive deficits on neuropsychological test results and evidence of impairment in social or occupational function (clinical dementia rating of ≥1). The diagnosis of AD was based on criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Associations.
Covariates & Analysis Detail
Cox proportional hazards regression
Follow-up time was the time scale in the proportional hazards analysis.
Nutrient intake was adjusted for total energy intake using the residual method (Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124:17-27).
APOE e4 genotype
coronary heart disease