Enter your keywords
HOME
About Us
NEWSLETTER
To search AlzRisk, use the "Keyword" search on the
AlzRisk search page
.
NEWS
All News
Conference Coverage
Series
WEBINARS
All Webinars
Databases
AlzBiomarker
AlzPedia
AlzRisk
Antibodies
Genetics
AlzGene
HEX
Mutations
Protocols
Research Models
Therapeutics
PAPERS
All Papers
Papers of the Week
Milestone
Alzforum Recommends
PROFESSIONAL RESOURCES
Conference Calendar
Grants
Jobs
Member Directory
ABOUT AD
AD Overview
Early-Onset Familial
The HBO Alzheimer's Project
Supported Browsers
MY ALZFORUM
My AlzForum Home
View Library
View Notifications
Set Notifications
Edit Profile
AlzRisk Paper Detail
Risk Factors
Alcohol
B Vitamins
Blood Pressure
Cognitive Activity
Diabetes Mellitus
Dietary Pattern
Head injury
Homocysteine
Hormone Therapy
Inflammatory Biomarkers
Non-Steroidal Anti-Inflammatory Drugs
Nutritional Antioxidants
Obesity
Physical Activity
Statin use
Reference:
Akbaraly, 2009
Cohort:
Three-City Study
Risk Factor:
Physical Activity
Average Follow-up Time Detail
While the study duration was four years, participants' average follow-up time was not reported.
Exposure Detail
"Leisure activities were assessed at baseline, using 2 different self-report frequency questionnaires, 1 questionnaire for daily leisure activities and 1 for monthly.
"...The frequency of participation for each of these activities was rated on a 3-point scale: 0, never or less than 1 hour per day; 1, 1–2 hours per day; 2, 2 hours per day. In the monthly questionnaire, participants were asked about monthly frequency (0, never or rarely; 1, 1–3 per month; 2, 1 per week; 3, 2 per week) with which they engaged in the following usual activities.
"...Within each type of frequency questionnaire, the categorization of leisure activities according to their predominantly mental, physical, or social characteristics was drawn from the existing literature.
15,16
"...Among the daily leisure activities, doing odd jobs, gardening, and going for a walk items are outside activities and were grouped together for their common physical characteristics as “physical leisure activities” (score ranging from 0 to 6, median score: 3."
Ethnicity Detail
The vast majority (97%) of participants were French speaking and 88% were born in France.
Screening and Diagnosis Detail
Screening Method:
BVRT
Benton Visual Retention Test (Benton 1974)
IST
Isaacs' Set Test (Isaacs & Kennie 1973)
MMSE
Mini-Mental State Examination (Folstein 1975)
AD Diagnosis:
NINCDS ADRDA
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Total dementia diagnosis:
DSM IV
Vascular dementia diagnosis:
NINDS-AIREN
Screening at baseline was based on a 3-step procedure: 1) battery of neuropsycholgical (BVT, IST, MMSE) tests by a trained psychologist 2) examination by a neurologist 3) an independent committee of neurologists reviewed all potential prevalent and incident cases of dementia to obtain a consensus on its diagnosis and etiology according to the criteria of the DSM-IV
Covariates & Analysis Detail
Analysis Type:
Cox proportional hazards regression
The exposure was analyzed categorically in tertiles.
The model described here was performed on 5698 participants for all-cause dementia and 5394 participants for AD.
AD Covariates:
A
age
E
education
G
gender
ADLI
activities of daily living impairment
APOE4
APOE e4 genotype
MMSE
baseline MMSE
DEP
depression
DM
diabetes mellitus
HC
high cholesterol
HTN
hypertension
MS
marital status
OS
Occupational status
SP
study population
VD
vascular disease
TD Covariates:
A
age
E
education
G
gender
ADLI
activities of daily living impairment
APOE4
APOE e4 genotype
MMSE
baseline MMSE
DEP
depression
DM
diabetes mellitus
HC
high cholesterol
HTN
hypertension
MS
marital status
OS
Occupational status
SP
study population
VD
vascular disease