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AlzRisk Paper Detail
Risk Factors
Alcohol
B Vitamins
Blood Pressure
Cognitive Activity
Diabetes Mellitus
Dietary Pattern
Head injury
Homocysteine
Hormone Therapy
Inflammatory Biomarkers
Non-Steroidal Anti-Inflammatory Drugs
Nutritional Antioxidants
Obesity
Physical Activity
Statin use
Reference:
Kim, 2008
Cohort:
Older adults in Kwangju, South Korea
Risk Factor:
Homocysteine
Exposure Detail
"Blood samples at baseline and follow-up were collected in a fasting state and were carried out in the mornings where possible. They were placed into EDTA tubes and centrifuged, separated into plasma aliquots and stored at 27 degrees Celsius within 2 h of collection."
Serum concentrations of total plasma homocysteine were measured by high performance liquid chromatography (AxSYM Homocysteine Reagent Pack; Abbott Laboratories, USA)
Change in plasma homocysteine levels over the follow-up period was categorized into ordinal quintiles for the analysis. The change in plasma homocysteine in the study population ranged from a 20-μmol/L decrease to a 25-μmol/L increase. However, the range of values for the individual quintiles was not given.
Screening and Diagnosis Detail
Screening Method:
CDR
Clinical Dementia Rating (Berg 1988) (CDR)
MMSE
Mini-Mental State Examination (Folstein 1975)
Neuropsych Testing
Other
AD Diagnosis:
DSM IV
Diagnostic and Statistical Manual IV
NINCDS ADRDA
National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association Criteria (McKhann 1984)
Investigators used the Korean version of the MMSE and the Instrumental Activities of Daily Living Scale to screen AD and dementia cases.
Covariates & Analysis Detail
Analysis Type:
Logistic regression
The effect estimates were computed per increase in one ordinal quintile of plasma homocysteine change over the follow-up period.
AD Covariates:
A
age
E
education
G
gender
ALC
alcohol intake
DEP
depression
DISAB
disability
PA
physical activity
CRT
serum creatinine
VITS
supplemental vitamin intake
VARS
vascular risk score
WTCH
weight change
TD Covariates:
A
age
E
education
G
gender
ALC
alcohol intake
DEP
depression
DISAB
disability
PA
physical activity
CRT
serum creatinine
VITS
supplemental vitamin intake
VARS
vascular risk score
WTCH
weight change